Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response
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Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response

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Published by National Institute of Neurological and Communicative Disorders and Stroke in [Bethesda, Md.? .
Written in English


  • GABA -- Physiological effect,
  • Neural transmission,
  • Brain -- Physiology

Book details:

Edition Notes

Other titlesLong term transformation of an inhibitory into an excitatory GABAergic synaptic response
StatementDaniel L. Alkon ... [et al.]
ContributionsAlkon, Daniel L, National Institute of Neurological and Communicative Disorders and Stroke
The Physical Object
Paginationp. 11862-11866 :
Number of Pages11866
ID Numbers
Open LibraryOL14713794M

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Hippocampal GABAergic inhibitory post synaptic currents (IPSCs) were found to be extremely labile, rapidly reduced by recurrent synaptic activation leading to the conclusion that the plasticity of inhibition is a major factor in epilepsies (Ben-Ari et al., a, Ben-Ari et al., a). The reversal of the chloride gradient was readily observed Cited by: To date, most studies on plasticity at GABAergic synapses have focused on GABA A-receptor mediated postsynaptic potentials (GABA A-PSPs).However, activation of either pre- or post-synaptic GABA B receptors during the conditioning protocol appears to have a key role in the induction of long-term plasticity at both GABA A ergic and glycinergic synapses (Figure a and Figure c) [4,22,31,35 Cited by: 3. An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential. IPSP were first investigated in motorneurons by David P. C. Lloyd, John Eccles and Rodolfo Llinás in the s and s. The opposite of an inhibitory postsynaptic potential is an excitatory postsynaptic potential (EPSP), which is a. Using a method based on the decomposition of the synaptic conductance into its excitatory and inhibitory components, we show that concomitant activation of D1-like receptors (D1Rs) and 5-HT1ARs.

The long-term stability and function of neuronal networks is dependent on a maintained balance between excitatory and inhibitory synaptic transmission. The major inhibitory neurotransmitter in the central nervous system is gamma-aminobutyric acid (GABA), which is converted from glutamate by the enzyme Glutamic Acid Decarboxylase (GAD). Synaptic strength in auditory brainstem and midbrain is sensitive to standard protocols for induction of long-term depression, potentiation, and spike-timing-dependent plasticity. In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action temporary depolarization of postsynaptic membrane potential, caused by the flow of positively charged ions into the postsynaptic cell, is a result of opening ligand-gated ion channels.   3. Excitatory synapses stimulate neurotransmitters while inhibitory synapses inhibit them. Latest posts by Emelda M (see all) Difference Between Mocha and Coffee - Janu Difference Between Verb and Predicate - January 2, Difference Between Tropical Meteorology and Monsoon Meteorology - January 2, /5(5).

hyperpolarizing graded potential that arises in postsynaptic neurons in response to activation of inhibitory synaptic endings upon it inhibitory synapse synapse that, when activated, decreases likelihood that postsynaptic neuron will fire an action potential (or decreases frequency of existing action potentials). Inhibitory synapses play a critical role in making sure that neurons maintain the appropriate level of activity. Dysfunctions in inhibitory synaptic transmission allows excitatory neurons to become over-active (disinhibition), resulting in seizures or strokes.-A second important function is regulating oscillatory activity in neural circuits. Inhibitory synapses. The neurotransmitter at inhibitory synapses hyperpolarizes the postsynaptic membrane.. Example: gamma aminobutyric acid (GABA) at certain synapses in the brain. The GABA A receptor is a ligand-gated chloride g of GABA to the receptors increases the influx of chloride (Cl −) ions into the postsynaptic cell raising its membrane potential and thus inhibiting it.   Biphasic, square‐wave pulses of 1 ms duration were adjusted to the intensity necessary for evoking ≈40% of a maximum field excitatory post‐synaptic potential (fEPSP) response. For long‐term potentiation (LTP) induction, a high‐frequency stimulation (HFS) was used consisting of Hz trains of 1‐s duration repeated five times with a Author: Irene Sánchez‐Rodríguez, Souhail Djebari, Sara Temprano‐Carazo, David Vega‐Avelaira, Raquel Jiménez‐.